List of Articles by MeSH

BONE MORPHOGENETIC PROTEINS

1. Macan D, Uglešić V, Knežević P, Potočki K, Šutić I, Jokić D, Keser I. Clinical Use of Bone Morphogenetic Protein rhBMP-7 in Implantology. Acta Stomatol Croat. 2008;42(1):100.
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   Title in English:	Clinical Use of Bone Morphogenetic Protein rhBMP-7 in Implantology
   Title in Croatian:	Klinička primjena koštanog morfogenetskog proteina rhBMP-7 u implantologiji
   Type of Article:	congress abstract
   MeSH:	BONE MORPHOGENETIC PROTEINS BONE REGENERATION DENTAL IMPLANTATION, ENDOSSEOUS MANDIBLE TRANSPLANTATION, AUTOLOGOUS
   Abstract:	Bone morphogenetic protein (BMP) is the most promising osteoinductive substance and has demonstrated the ability to stimulate bone regeneration. Several animal studies confirmed that the application of bone morphogenetic proteins caused a more rapid and enhanced osseointegration of simultaneously placed implants when compared to the bone substitute alone. To our knowledge, only two case reports presented clinical use of BMP-7 in maxillofacial surgery (maxillary sinus floor elevation; Le Fort I osteotomy and advancement).We present patient with recurrent ameloblastoma treated by segmental osteotomy of the mandible. The bone defect (6 cm length) was reconstructed by autogenous iliac crest bone grafts using BMP-7 (Stryker Biotech, USA). Radiographic evidence of new bone formation was seen at 9 months, postoperatively. A biopsy was taken at 9 months demonstrated viable new bone formation. A year after the reconstruction we have inserted three dental implants (Ankylos ®, Friadent, Germany). One implant failed, and two years after the insertion we have loaded two implants with ceramic bridge. Follow-up period is two years. To our knowledge, this is the first described case of dental implants inserted in resected mandible reconstructed by bone graft using bone morphogenetic protein. The problem of BMP-7 dosage and overgrowth of the graft should be discussed. Although this case has shown encouraging results, long-term results and the predictability of nthis type of reconstruction in humans are still unknown.

2. Vukičević S. The Role of Bone Morphogenetic Proteins in Rregeneration of Bone and Cartilage. Acta Stomatol Croat. 2002;36(3):314-5.
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   Title in English:	The Role of Bone Morphogenetic Proteins in Rregeneration of Bone and Cartilage
   Title in Croatian:	nema
   Type of Article:	congress abstract
   MeSH:	BONE REGENERATION CARTILAGE BONE MORPHOGENETIC PROTEINS
   Abstract:	In the last ten years a significant amount of knowledge has accumulated in the field of molecular and developmental biology. New genes responsible for the skeleton development have been discovered, and their function in the postnatal life of mammals has been defined. The most important genes responsible for the morphogenesis on all three embryonic envelopes include bone morphogenetic proteins (BMPs) and cartilage derived morphogenetic proteins (CDMPs), recently renamed into morphogens. Sincetheir discovery, many investigators world wide have defined the morphogen receptors, signal transduction pathways, and their role in several organs. Recently, the use of recombinant human BMPs in the regeneration of long bones and the craniofacial skeleton in patients with bone non-unions have been approved in Europe, USA, Canada and Australia. In pre clinical studies it has been demonstrated that locally applied BMP-7 initiates cementogenesis, and the regenerationof periodontal ligament and the alveolar bone. CDMPs have a promising role in articular cartilage regeneration and are also good candidates for clinical trials in humans.

3. Filipović-Zore I, Katanec D, Sušić M, Dodig D, Mravak-Stipetić M, Knezović-Zlatarić D. Bone morphogenetic proteins - new hope in the reconstruction of bone defects in the stomatognathic area. Acta Stomatol Croat. 2000;34(3):311-24.
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   Title in English:	Bone morphogenetic proteins - new hope in the reconstruction of bone defects in the stomatognathic area
   Title in Croatian:	Morfogenetski proteini kosti - nova nada u rekonstrukciji koštanih defekata stomatognatoga područja
   Type of Article:	review
   MeSH:	BONE MORPHOGENETIC PROTEINS BONE REGENERATION ALVEOLAR BONE LOSS + therapy PERIODONTIUM REGENERATION PERIODONTAL DISEASES + therapy
   Abstract:	Bone morphogenetic proteins are a group of nine known proteins which represent factors of growth and differentiation with the ability of inducing new bone. Osteoinduction is a precisely defined sequence of biological reactions which lead to the transformation of mesenchymal cells into cartilage and bone.In vitro and in vivo, studies have demonstrated that in order for proteins to realise their clinical function they need carriers. So far ACS (absorbable collagen sponge) has been most frequently used as a carrier. However the search for the best carrier continues. Investigations carried out so far on experimental models (rats, dogs, minipigs and chimpanzees), and in human volunteers, have indicated the great potential of BMP in the reconstruction of bone defects of the stomatognathic area. Promising results have been obtained so far in periodontal surgery, augmentation of alveolar ridges, augmentation of the floor of the maxillary sinus, treatment of periimplantitis and treatment of larger bone defects after extirpation of tumours.