List of Articles by MeSH

BONE REGENERATION

NOTES:

*Articles are cited according to Uniform Requirements by International Committee of Medical Journal Editors - ICMJE and NLM Style Guide for Authors, Editors and Publishers

Macan D, Uglešić V, Knežević P, Potočki K, Šutić I, Jokić D, Keser I. Clinical Use of Bone Morphogenetic Protein rhBMP-7 in Implantology. Acta Stomatol Croat. 2008;42(1):100.

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Title in English:	Clinical Use of Bone Morphogenetic Protein rhBMP-7 in Implantology
Title in Croatian:	Klinička primjena koštanog morfogenetskog proteina rhBMP-7 u implantologiji
Type of Article:	congress abstract
MeSH:	BONE MORPHOGENETIC PROTEINS BONE REGENERATION DENTAL IMPLANTATION, ENDOSSEOUS MANDIBLE TRANSPLANTATION, AUTOLOGOUS
Abstract:	Bone morphogenetic protein (BMP) is the most promising osteoinductive substance and has demonstrated the ability to stimulate bone regeneration. Several animal studies confirmed that the application of bone morphogenetic proteins caused a more rapid and enhanced osseointegration of simultaneously placed implants when compared to the bone substitute alone. To our knowledge, only two case reports presented clinical use of BMP-7 in maxillofacial surgery (maxillary sinus floor elevation; Le Fort I osteotomy and advancement).We present patient with recurrent ameloblastoma treated by segmental osteotomy of the mandible. The bone defect (6 cm length) was reconstructed by autogenous iliac crest bone grafts using BMP-7 (Stryker Biotech, USA). Radiographic evidence of new bone formation was seen at 9 months, postoperatively. A biopsy was taken at 9 months demonstrated viable new bone formation. A year after the reconstruction we have inserted three dental implants (Ankylos ®, Friadent, Germany). One implant failed, and two years after the insertion we have loaded two implants with ceramic bridge. Follow-up period is two years. To our knowledge, this is the first described case of dental implants inserted in resected mandible reconstructed by bone graft using bone morphogenetic protein. The problem of BMP-7 dosage and overgrowth of the graft should be discussed. Although this case has shown encouraging results, long-term results and the predictability of nthis type of reconstruction in humans are still unknown.

Brajdić D, Macan D. Alveolar Bone Reconstruction for Implant Placement in Anterior Maxilla. Acta Stomatol Croat. 2008;42(1):99-100.

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Title in English:	Alveolar Bone Reconstruction for Implant Placement in Anterior Maxilla
Title in Croatian:	Rekonstrukcija dijela alveolarnog grebena za postavu dentalnih implantata u prednjoj maksili
Type of Article:	congress abstract
MeSH:	DENTAL IMPLANTATION, ENDOSSEOUS DENTAL IMPLANTS MAXILLA ALVEOLAR BONE LOSS TRANSPLANTATION, AUTOLOGOUS BONE REGENERATION
Abstract:	Reconstruction of demanding areas represent a particular clinical challenge in implant dentistry. These are mostly atrophic regions with sinus recesses, as well as the region close to the nasal cavity in the anterior part of the maxilla. In mandible, the vertical atrophy laterally leads to the inability to place implants to the proximity of the alveolar nerve in one procedure. Horizontal atrophy can cause inability to place implants, even when the vertical dimension is satisfactory. A combination of these findings is especially demanding in the anterior parts of maxilla, due to the functional and esthetic requirements of prosthetic reconstructions. We show three cases of extreme resorption in anterior maxilla, where one teeth was missing. First is a case of horizontal resorption with two cortical plates joined together and the crest width of 3 mm. By expanding the crest we were able to place an implant (Ankylos®, Friadent, Germany) in the same procedure. Second case was extensive resorption of the vestibular socket wall, where we were able to regain bone by combining xenogene (Bio- Oss® - Geistlich Biomaterials, Switzerland) and autologous bone material and by covering it with a resorbable membrane (Bio-Gide® - Geistlich Biomaterials, Switzerland). After 4 months of healing an implant was placed in the regenerated bone (Ankylos), with satisfactory primary stability. Third case was a situation of extenstive horizontal and vertical resorption, similar to the first case. By using resorbable membrane on both sides of the defect and a mixture of xenogenous and autologous bone material, and a block transplant fixated with a screw, we obtained acceptable bakterijbone dimension for implant placement after 4 months of healing.

Tahmiščija H, Radović S, Topić B, Tahmiščija N, Laux T, Arifhodžić F. Guided Bone Regeneration with Application of Titanium Membrane (Clinical experience). Acta Stomatol Croat. 2003;37(3):382-3.

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Kobler P, Živko-Babić J, Borčić J. Guided Bone Regeneration in Dental Implant Treatment - a Case Report. Acta Stomatol Croat. 2003;37(3):347-8.

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Joudzbalys G, Bojarskas S. Peculiarities of Implantation in the Posterior Mandible. Acta Stomatol Croat. 2003;37(1):75-84.

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Adamczyk E, Gladkowski J, Machnikowski I, Mierzwinska E, Spiechowicz E, Feder T, Wojtowicz A, Matenko D, Ciechowicz K. Utilization of Guided Bone Regeneration Techniqes in Treatment of a Single Tooth Missing with Implant Supported Crown. Acta Stomatol Croat. 2002;36(3):317.

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Vukičević S. The Role of Bone Morphogenetic Proteins in Rregeneration of Bone and Cartilage. Acta Stomatol Croat. 2002;36(3):314-5.

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Filipović-Zore I, Katanec D, Sušić M, Dodig D, Mravak-Stipetić M, Knezović-Zlatarić D. Bone morphogenetic proteins - new hope in the reconstruction of bone defects in the stomatognathic area. Acta Stomatol Croat. 2000;34(3):311-24.

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Sušić M, Kobler P, Macan D, Filipović-Zore I, Verzak Ž, Katanec D. Clinical and radiographic investigation of bone defects following the application of a collagen matrix. Acta Stomatol Croat. 2000;34(3):273-85.

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Title in English:	Clinical and radiographic investigation of bone defects following the application of a collagen matrix
Title in Croatian:	Kliničko i radiološko ispitivanje koštanih defekata nakon upor / kolagenog matriksa
Type of Article:	original scientific paper
MeSH:	ALVEOLAR BONE LOSS + therapy BONE MATRIX BONE SUBSTITUTES BONE REGENERATION APICOECTOMY PERIODONTITIS + surgery TRANSPLANTATION, HETEROLOGOUS
Abstract:	Large bone defects of the jaw have, so far, been filled with various types of bone implants, mainly synthetic nonresporative aloplastic implants (hydroxilapatite). As we have data only for two types of resorptive xenogenic bone implants, the purpose of this investigation was to examine resorption and osteoinductive capability of OSTEOVIT as a material for filling bone defects after removing large cysts (more than 20 mm in diameter) and after apicectomy of the tooth, where more than 1/3 of the tooth has no strong bone bases.Osteovit is a collagen matrix of calf spongiose consisting of porous collagen purified of antigens, fats minerals, enzymes and all other noncollagen materials.Forty-one patients, 9 female and 32 male aged 15-54 years were included in the investigation Nineteen of them had a clinical diagnosis of OPC and 22 a clinical diagnosis of cysts radicularis. All patients had a indication for apicectomy indicating that they had bone defects larger than 20 mm in diameter or destructive alveolus along more than 1/3 of the tooth root.The results are shown on the basis of a clinical follow up and radiographic examination 6 months, 1,2,3 and 4 years after surgery. If, in some cases, a fistula was found during the postoperative followup the treatment was recorded as clinically unsuccessful. Success on the basis of radiographic criteria was also evaluated. First we classified defects into periapical (circumscriptive) and those along the tooth root and than divided the rays into two groups.Unfortunately results for only for 22 patients were abtained and the others were excluded from the investigation because of incomplete follow-up.With regard to total success, according to clinical criterium, 20/22 patients had good clinical diagnosis, i.e. 91%. By radiographic analysis we found complete healing in 13/22 patients or 59%. We also analysed results according to the localization of the periapical change. It was concluded that patients with circumscriptive changes were 88% clinically successful while those with a defect along the tooth root were 93% clinically successful.According to the results of this investigation it can be concluded that OSTEOVIT is a very good resorptive material for filling bone defects and with OSTEOVIT it is possible to widen indication for apicotomy to include cases where more than 1/3 of the tooth has no strong bone base.

Ivić-Kardum M, Škunca-Ograjšek D, Katanec D, Sušić M. Application of polyglycolic-polylactic synthetic co-polymer in periodontal intrabony defects. Acta Stomatol Croat. 2000;34(2):207-17.

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Title in English:	Application of polyglycolic-polylactic synthetic co-polymer in periodontal intrabony defects
Title in Croatian:	Uporaba poliglikolno-polilaktičnoga sintetskog kopolimera u parodontnim intrakoštanim defektima
Type of Article:	case report
MeSH:	BIOCOMPATIBLE MATERIALS POLYMERS ALVEOLAR BONE LOSS + therapy BONE REGENERATION
Abstract:	The paper presents two cases of clinical application of polyglycolicpolylactic co-polymer Fisiograft. In the first case periodontal abscess and damaged interradicular alveolar bone of tooth 46 was diagnosed. Interradicular damage to the bone was visible after opening the mucoperiosteal flap. Scaling of the root and careful elimination of the inflamed tissue was performed and the defect filled with Fisiograft implant (Ghimas S.p.A - Italy) in the form of gel and powder, moistened with blood and covered with a coronally positioned flap. Postoperatively the patient was advised to rinse her mouth with 0.2% chlorhexidine digluconate solution. The results of the treatment were monitored clinically and radiographically six months after the procedure. Probing the periodontal pockets before the procedure revealed a depth of 8 mm and loss of the level of periodontal attachment of 10 mm on tooth 46. Clinical evaluation six months after the procedure showed a reduction in the depth of the periodontal pocket from 8 to 4 mm and attachment level gain of 5 mm, which amounts to 50% of the original defect. In the second case, after raising the mucoperiosteal flap of tooth 21, an extensive intrabony defect was revealed, which involved several bony walls. After scaling and planing the root we filled the defect with a Fisiograft implant in the form of gel and powder, moistened with blood. Because of the activity of the periodontal pocket we prescribed Amoxicilin tablets 500 mg, 3 times daily for 5 days. Postoperatively, the patient was advised to rinse his mouth with 0.2% chlorhexidine digluconate solution. Six months after the procedure the clinical finding showed reduced depth of the periodontal pocket and gain of attachment level 4 mm, i.e. 44.5% of the original clinical defect. The radiograph showed reduced radiolucency of the alveolar bone of tooth 21, indicating the formation of new supporting alveolar bone. Thus, it can be said that the application of Fisiograft proved to be successful in regeneration of the alveolar intrabony defect. Six months after the procedure the radiograph showed considerably reduced radiolucency and depth of the periodontal pocket was reduced by around 50%.In the presented two cases the application of Fisiograft proved successful in the process of healing alveolar bone, damaged by periodontitis, and it is therefore proposed that this implant is applied in a larger number of subjects and further investigation carried out.

Švajhler T, Filipović-Zore I, Kobler P, Rainer H, Macan D. Vođena regeneracija kosti-istraživanje na eksperimentalnim životinjama [in Croatian]. Acta Stomatol Croat. 1998;32(Suppl):188.

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Jukić S, Anić I, Talan Hranilović J, Najžar-Fleger D. The effects of CO" and Nd:YAG lasers on periodontal tissue in the furcations of molars. Acta Stomatol Croat. 1998;32(4):557-66.

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Jorgić-Srdjak K, Plančak D, Potočki-Tukša K. [Guided tissue regeneration in the reconstructive periodontal surgery]. Acta Stomatol Croat. 1996;30(3):207-14.

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