List of Articles by MeSH

BONE SUBSTITUTES

NOTES:

*Articles are cited according to Uniform Requirements by International Committee of Medical Journal Editors - ICMJE and NLM Style Guide for Authors, Editors and Publishers

Gabrić Pandurić D, Sušić M, Kobler P, Pelivan I. Possibility of β-tricalcium Phosphate Use in Implant Dentistry. Acta Stomatol Croat. 2008;42(1):110.

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Title in English:	Possibility of β-tricalcium Phosphate Use in Implant Dentistry
Title in Croatian:	Mogućnost primjene β-trikalcijsfosfata u dentalnoj implantologiji
Type of Article:	congress abstract
MeSH:	DENTAL IMPLANTATION, ENDOSSEOUS DENTAL IMPLANTS TRANSPLANTATION, AUTOLOGOUS BONE SUBSTITUTES ALVEOLAR RIDGE AUGMENTATION
Abstract:	Xenogenous and alloplastic materials are frequently used in implant dentistry today. Mostly they are used in combination with autologous bone transplant in dehiscences and fenestrations of implants, and in post-extraction augmentation of sockets for preservation of bone height and width. Easy-Graft™ (Biodegradable Solutions AG, Switzerland) is a beta-tricalcium phosphate material in granules that are covered with a micrometer layer of polylactic acid. Coated granules are transformed into a sticky material by the activator, enabling the clinician to apply the material directly from a syringe. In contact with blood it hardens and mimics the shape of the defect and stays mechanically stable. This is 100% synthetic, completely resorbable material that is substituted by bone in some months. We are showing 3 cases where Easy-Graft™ has been used in combination with dental implant or in preparation of the site for implant placement. Use of Easy-Graft™ in the postextraction socket of the first upper premolar that was extracted due to the vertical fracture of the root, in order to prevent the collapse of socket walls and horizontal resorption of the crest. Use of the material simultaneously with implant placement in the area of the left central incisor for the augmentation of the circumferential defect that was caused by the horizontal resorption of the alveolar crest. Use of the material simultaneously with implant placement in the area of the left second upper premolar with a vestibular dehiscence, in combination with autologous bone material. We can conclude that Easy-Graft™ can be used in implant dentistry in various clinical cases due to its simple application and resorbability.

Vlah M, Bošnjak A, Meniga A. Postekstrakcijska augmentacija alveola modificiranim beta-trikalcijevim fosfatom. Acta Stomatol Croat. 2008;42(1):110-1.

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Title in English:	Postekstrakcijska augmentacija alveola modificiranim beta-trikalcijevim fosfatom
Title in Croatian:	Postekstrakcijska augmentacija alveola modificiranim beta-trikalcijevim fosfatom
Type of Article:	congress abstract
MeSH:	TOOTH EXTRACTION BONE SUBSTITUTES ALVEOLAR RIDGE AUGMENTATION DENTAL IMPLANTATION, ENDOSSEOUS
Abstract:	Preservation of bone volume after tooth extraction is of great importance for the functional and esthetic success of implanto-prosthetic treatment. There is no data on the success of the tested beta-tricalcium phosphate augmentation material for the preservation of bone volume after extraction. In order to test it, we chose 12 patients that had an indication for single tooth extraction (vertical fracture or internal resorption). Teeth were extracted by an atraumatic procedure using Periotome® (NobelBiocare, Sweden). After careful cleaning of the wound and rinsing with 0.9% saline the socket was augmented with aloplastic material consisting of 60% crystallinic hydroxiapatite and 40% beta-tricalcium phosphate (Bone Ceramic, Straumann AG, Switzerland, particle size 500-1000 μm). A gelatine tampone with 5% colloid silver (Gelatamp, Roeko, Coltene/Whaledent, Germany) was placed over the augmented material, and a cross-suture of expanded polytetrafluorethilene (Gore-Tex CV-5 or CV-6, WL Gore & Associates, Inc., USA) was placed over it to hold it in place. The suture was removed 10 days after extraction, and the patients were instructed to rinse once daily with 0.12% solution of chlorhexidine-digluconate (Curasept ADS 212, Curaden, Switzerland). Control radiograph was taken after the procedure and minimally 3 months after the extraction, when a titanium implant (diameter 3.9 mm, Ospol AB, Sweden) was placed in the healed socket. All implants had primary stability of at leas 35 Ncm, and a temporary crown was placed on them. Bone volume was retained, and augmentation material ensured good primary stability after healing time of at least 3 months.

Sušić M, Gabrić Pandurić D, Ćatić A, Kobler P. Immediate Nonfunctional Load in the Esthetic Zone: Case Report. Acta Stomatol Croat. 2008;42(1):106.

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Božić D, Sever L, Plančak D. Successful Regenerative Therapy of a Periimplant Defect: One Year Result. Acta Stomatol Croat. 2008;42(1):104.

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Title in English:	Successful Regenerative Therapy of a Periimplant Defect: One Year Result
Title in Croatian:	Uspješna regenerativna terapija periimplantatnog defekta: rezultat nakon jedne godine
Type of Article:	congress abstract
MeSH:	DENTAL IMPLANTATION, ENDOSSEOUS ALVEOLAR BONE LOSS TRANSPLANTATION, AUTOLOGOUS BONE SUBSTITUTES
Abstract:	Two implants were inserted in patient’s region 24 and 25. After six months of healing, before implant uncovering, a fistula was observed above implant 24. Radiographic imaging showed great bone loss around the implant, and the reason for the infection was vertical fracture of tooth 23. It was decided to be treated by a regenerative procedure. After applying local anesthetic the incision was performed vertically 10 mm behind the implant 25 and 5-6 mm palatally from the alveolar crest, finishing with the vertical incision mesially from 23. After flap reflection tooth 23 was extracted and granulation tissue was removed so that the 5 mm depth circumferential defect could be displayed. Palatally, the defect was 3 mm vertically. After implant surface was cleansed with cotton pellet soaked in chlorhexidine, implant surface was covered with autogenous bone, and over it xenogenous material (Biogen-mix, Bioteck, Italy) was placed in a manner that the volume of the transplanted material was 30 % greater than the alveolar crest to compensate for the material resorption. A collagen membrane was placed in two layers over the material (Bio-Gide® - Geistlich Biomaterials, Switzerland). After a periostal incision and repositioning the flap, it was sutured by horizontal mattress and interrupted sutures. Two weeks after operation the sutures were removed, and there was no membrane exposure during the healing period. Six months postoperatively a control radiograph showed healing of the periimplant defect. The implants were uncovered and in 6 weeks the impression was taken and zirconia crowns were cemented. One year after functional loading radiographs showed stable regenerated bone around the implant.

Gorjanc M. Guided Implant Surgery in Cleft Lip and Palate (CLP) Patient: a Promising Way in Overcoming Morphologic Problems in Implantology. Acta Stomatol Croat. 2008;42(1):102.

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Title in English:	Guided Implant Surgery in Cleft Lip and Palate (CLP) Patient: a Promising Way in Overcoming Morphologic Problems in Implantology
Title in Croatian:	Navođena implantacija kod pacijenta s rascjepom usnice i nepca (CLP): obećavajući način svladavanja morfoloških problema u dentalnoj implantologiji
Type of Article:	congress abstract
MeSH:	DENTAL IMPLANTATION, ENDOSSEOUS CLEF LIP CLEF PALATE TRANSPLANTATION, AUTOLOGOUS BONE SUBSTITUTES ALVEOLAR BONE LOSS
Abstract:	Bilateral cleft lip and palate is a congenital malformation characterized by morphologic changes and deficiencies of soft and hard tissues in oral and maxillofacial region. Surgical correction usually takes place in childhood, but some problems can show up later. Beside the essential hypodontia in the cleft region, tooth loss due to other etiologic factors can contribute to edentoulism in adult patients. We present a case of 52-years old male patient with bilateral CLP. After surgical correction in the childhood, patient led a normal life with compensated function of the stomatognathic system. Problems arised, when he lost his last four maxillary teeth that supported his denture. Due to particular morphology of the ridges, removable prosthetic solution was only partly satisfying his needs. After consultation with the prosthodontist, we decided for implant supported solution. Preliminary dental CT showed atrophic bony ridges that excluded the possibility of orthotopic implant placement. As the patients resources were limited and extensive sinus lifts were out of his range, we decided for a compromise: autologous retromolar bone graft to the left premolar region, where we were facing the least bone quantity, was performed first. The gained bone volume was established on an additional dental CT and computer aided planning, was performed for placement of four maxillary implants. Planning culminated in fabrication of mucosa supported surgical guide (Simplant, Materialise) and was followed by successful placement of the implants. We conclude that computer aided planning and guided implant surgery make the extreme surgical precision possible and predictable. This is of utmost importance in situations with scarce bone quantity, where every millimeter of residual bone can be a landmark between failure and success.

Rebić J, Macan D, Grgurević L. Immediate Implant Placement in a Previously Infected Alveola: Case Report. Acta Stomatol Croat. 2008;42(1):101.

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Title in English:	Immediate Implant Placement in a Previously Infected Alveola: Case Report
Title in Croatian:	Imedijatna implantacija u primarno inficiranu alveolu: prikaz slučaja
Type of Article:	congress abstract
MeSH:	DENTAL IMPLANTATION, ENDOSSEOUS DENTAL IMPLANTS, SINGLE-TOOTH DENTAL PORCELAIN ALVEOLAR RIDGE AUGMENTATION BONE SUBSTITUTES
Abstract:	We present a case report of immediate implant placement with augmentation of xenogenous bone material in a 36-year-old patient after upper first molar extraction with progressive periodontitis. Lindeboom et al. found 8% of complications in immediate implant placement in locations with periapical infection, while Schwartz et al. found 56.7% complications after implant placement in patients with infective posttraumatic processes. Both authors agree that immediate implant placement can be used with predictable results and that the inflammatory process on an implant site does not have to influence the outcome of implant placement and prosthetic restoration. After clinical and radiographic examination the extraction of tooth 16 was indicated. The decision on immediate implant placement was achieved due to the possible intra- and postoperative complications regarding late implantation and prolonged time of prosthetic treatment after sinus lift procedure. Alveola was curetted after extraction; during wall integrity examination we determined the position of the future implant, but there was no acceptable length. Osteotomes were used to deepen the osteotomy, and screw tap was used to form the site for the implant. Prepared site was augmented with 500 mg of xenogenous bone material (Bio-Oss®, Geistlich Biomaterials, Switzerland). Ankylos B11 implant was placed in the osteotomy and covered with a resorbable membrane (Bio-Gide® Geistlich Biomaterials, Switzerland). Mucoperiosteal flap was mobilized by cutting the periosteum, and sutured back in place. Six months after implant placement a healing abutment was placed. Two weeks later an impression was taken and shade of the future crown was determined. Ankylos Balance Posterior abutment was screwed onto the implant and the finished crown was cemented.

Cerović R, Juretić M, Belušić-Gobić M. Sinus Lift With Immediate Implant Placement. Acta Stomatol Croat. 2008;42(1):100.

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Lorenzoni M. Bone Substitutes: Success and Challenges. Acta Stomatol Croat. 2008;42(1):95.

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Krenkel C. Bony Reconstruction and Implantology for Full Rehabilitation of the Masticatory Apparatus. Acta Stomatol Croat. 2008;42(1):94.

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Title in English:	Bony Reconstruction and Implantology for Full Rehabilitation of the Masticatory Apparatus
Title in Croatian:	Koštana rekonstrukcija i implantologija u potpunoj rehabilitaciji žvačnog sustava
Type of Article:	congress abstract
MeSH:	DENTAL IMPLANTATION, ENDOSSEOUS ALVEOLAR BONE LOSS TRANSPLANTATION, AUTOLOGOUS BONE SUBSTITUTES ALVEOLAR RIDGE AUGMENTATION
Abstract:	The introduction of implant-prosthetic rehabilitation of our patients in everyday dental practice has notably improved the quality of living. Such procedures can successfully resolve many functional and esthetic problems; however, some difficult cases, which require long-term and extensive intervention, still remain. First and foremost being severe jaw atrophy, where the alveolar process is no longer present. Such conditions are more frequent in the lower jaw where the stability and retention of lower complete dentures represent a leading problem in dentistry. The main cause of severe atrophies is early tooth loss, which was not prosthetically substituted. In such patients it is necessary to increase the mass of and build up the jawbone (augmentation). In those cases artificial bone is used (inorganic parts of animal bones or synthetic materials) or even bone autotransplantation. Autologus bone has shown to be successful, but it requires the opening of yet another operative field in the lower jaw (chin, retromolar area), crista iliaca or parietal bone (calvaria graft). Sometimes, depending on indications, simultaneous implant setting is performed. In more difficult cases, it is necessary to first increase the bone mass, wait 4 to 6 weeks for the integration of the autologus bone and only then perform the implantation. After the implant is fixated with small screws, we must carefully fixate the periosteal layer with resorbing sutures to ensure the operative field is covered with a double layer. The patients should not wear dentures during this time.In the lateral segment of the upper jaw, sinus lifting is performed in cases with severe atrophies and alveolar resorption of the maxillary sinus. At times simultaneously with implantation, where as in more difficult cases only sinus lifting is performed and implantation follows 4 to 6 months after.Nowadays, severe atrophies of the lower jaw (classes 5 and 6 according to Watzek) are solved with bone endo-distraction. For that purpose, special instruments were constructed and hollow implants (distractors) which after osteotomy of the lower jaw, are embedded in the osteotomised section of the lower jaw. We use one or two distractors. Gradually turning the distraction screw which passes through the hollow implant, we way we stimulate callus formation or bone growth between the described sections. With the described procedure, we can noticeably increase and heighten the front of the lower jaw. We often insert 4 implants after 3 to 4 months and make a prosthetic suprastructure with an extended bar onto which the cover denture is attached. Thus, good functional and esthetic results are achieved. In the described procedure, so far there has not been any secondary implant loss or development of periimplantitis.

Sušić M, Kobler P, Macan D, Filipović-Zore I, Verzak Ž, Katanec D. Clinical and radiographic investigation of bone defects following the application of a collagen matrix. Acta Stomatol Croat. 2000;34(3):273-85.

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Title in English:	Clinical and radiographic investigation of bone defects following the application of a collagen matrix
Title in Croatian:	Kliničko i radiološko ispitivanje koštanih defekata nakon upor / kolagenog matriksa
Type of Article:	original scientific paper
MeSH:	ALVEOLAR BONE LOSS + therapy BONE MATRIX BONE SUBSTITUTES BONE REGENERATION APICOECTOMY PERIODONTITIS + surgery TRANSPLANTATION, HETEROLOGOUS
Abstract:	Large bone defects of the jaw have, so far, been filled with various types of bone implants, mainly synthetic nonresporative aloplastic implants (hydroxilapatite). As we have data only for two types of resorptive xenogenic bone implants, the purpose of this investigation was to examine resorption and osteoinductive capability of OSTEOVIT as a material for filling bone defects after removing large cysts (more than 20 mm in diameter) and after apicectomy of the tooth, where more than 1/3 of the tooth has no strong bone bases.Osteovit is a collagen matrix of calf spongiose consisting of porous collagen purified of antigens, fats minerals, enzymes and all other noncollagen materials.Forty-one patients, 9 female and 32 male aged 15-54 years were included in the investigation Nineteen of them had a clinical diagnosis of OPC and 22 a clinical diagnosis of cysts radicularis. All patients had a indication for apicectomy indicating that they had bone defects larger than 20 mm in diameter or destructive alveolus along more than 1/3 of the tooth root.The results are shown on the basis of a clinical follow up and radiographic examination 6 months, 1,2,3 and 4 years after surgery. If, in some cases, a fistula was found during the postoperative followup the treatment was recorded as clinically unsuccessful. Success on the basis of radiographic criteria was also evaluated. First we classified defects into periapical (circumscriptive) and those along the tooth root and than divided the rays into two groups.Unfortunately results for only for 22 patients were abtained and the others were excluded from the investigation because of incomplete follow-up.With regard to total success, according to clinical criterium, 20/22 patients had good clinical diagnosis, i.e. 91%. By radiographic analysis we found complete healing in 13/22 patients or 59%. We also analysed results according to the localization of the periapical change. It was concluded that patients with circumscriptive changes were 88% clinically successful while those with a defect along the tooth root were 93% clinically successful.According to the results of this investigation it can be concluded that OSTEOVIT is a very good resorptive material for filling bone defects and with OSTEOVIT it is possible to widen indication for apicotomy to include cases where more than 1/3 of the tooth has no strong bone base.

Štambuk D, Macan D, Kobler P, Knežević G, Štambuk L. [Use of tricalcium phosphate ceramics for periapical jaw defect filling]. Acta Stomatol Croat. 1995;29(4):243-51.

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