List of Articles by MeSH

ALVEOLAR BONE LOSS + therapy

1. Krmpotić M, Jelušić D. The Problems of Transplantation in the Distal Region of the Atrophic Upper Jaw - Implantation Techniques and Case Presentation. Acta Stomatol Croat. 2005;39(3):261.
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   Title in English:	The Problems of Transplantation in the Distal Region of the Atrophic Upper Jaw - Implantation Techniques and Case Presentation
   Title in Croatian:	Problematika implantacije u distalnoj regiji atrofične gornje čeljusti - implantacijske tehnike i prikazi slučajeva
   Type of Article:	congress abstract
   MeSH:	DENTAL IMPLANTATION + methods TRANSPLANTATION ALVEOLAR BONE LOSS + therapy
   Abstract:	The insertion of an implant in the distal region of the atrophic upper jaw is usually a technically demanding surgical intervention. Most commonly the problem is a lowered maxillary sinus. The presentation describes the bases of the following surgical techniques: 1. bypassing the sinus - insertion of the implant alongside the medial wall of the sinus (without penetration into the sinus cavity), with slight distal inclination; 2. transcrestal condensation of the sinus floor by osteotomes (Summers-technique) - combined preparation by drills and osteotomes with final osteotomy of the sinus floor without perforation of the mucous membrane; 3. open method of lifting the sinus floor by the vestibular approach - classical method of approach through the opening in the vestibular wall of the sinus, preparation and pressing of the mucous membrane, and inserting of material for augmentation (simultaneously with the insertion implant, or in two phases). Each method is supplemented with a presentation of clinical cases.Knowledge of all three methods enables the experienced clinician to solve all situations in implantological treatment of distal regions in the upper jaw.

2. Filipović-Zore I, Katanec D, Sušić M, Dodig D, Mravak-Stipetić M, Knezović-Zlatarić D. Bone morphogenetic proteins - new hope in the reconstruction of bone defects in the stomatognathic area. Acta Stomatol Croat. 2000;34(3):311-24.
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   Title in English:	Bone morphogenetic proteins - new hope in the reconstruction of bone defects in the stomatognathic area
   Title in Croatian:	Morfogenetski proteini kosti - nova nada u rekonstrukciji koštanih defekata stomatognatoga područja
   Type of Article:	review
   MeSH:	BONE MORPHOGENETIC PROTEINS BONE REGENERATION ALVEOLAR BONE LOSS + therapy PERIODONTIUM REGENERATION PERIODONTAL DISEASES + therapy
   Abstract:	Bone morphogenetic proteins are a group of nine known proteins which represent factors of growth and differentiation with the ability of inducing new bone. Osteoinduction is a precisely defined sequence of biological reactions which lead to the transformation of mesenchymal cells into cartilage and bone.In vitro and in vivo, studies have demonstrated that in order for proteins to realise their clinical function they need carriers. So far ACS (absorbable collagen sponge) has been most frequently used as a carrier. However the search for the best carrier continues. Investigations carried out so far on experimental models (rats, dogs, minipigs and chimpanzees), and in human volunteers, have indicated the great potential of BMP in the reconstruction of bone defects of the stomatognathic area. Promising results have been obtained so far in periodontal surgery, augmentation of alveolar ridges, augmentation of the floor of the maxillary sinus, treatment of periimplantitis and treatment of larger bone defects after extirpation of tumours.

3. Sušić M, Kobler P, Macan D, Filipović-Zore I, Verzak Ž, Katanec D. Clinical and radiographic investigation of bone defects following the application of a collagen matrix. Acta Stomatol Croat. 2000;34(3):273-85.
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   Title in English:	Clinical and radiographic investigation of bone defects following the application of a collagen matrix
   Title in Croatian:	Kliničko i radiološko ispitivanje koštanih defekata nakon upor / kolagenog matriksa
   Type of Article:	original scientific paper
   MeSH:	ALVEOLAR BONE LOSS + therapy BONE MATRIX BONE SUBSTITUTES BONE REGENERATION APICOECTOMY PERIODONTITIS + surgery TRANSPLANTATION, HETEROLOGOUS
   Abstract:	Large bone defects of the jaw have, so far, been filled with various types of bone implants, mainly synthetic nonresporative aloplastic implants (hydroxilapatite). As we have data only for two types of resorptive xenogenic bone implants, the purpose of this investigation was to examine resorption and osteoinductive capability of OSTEOVIT as a material for filling bone defects after removing large cysts (more than 20 mm in diameter) and after apicectomy of the tooth, where more than 1/3 of the tooth has no strong bone bases.Osteovit is a collagen matrix of calf spongiose consisting of porous collagen purified of antigens, fats minerals, enzymes and all other noncollagen materials.Forty-one patients, 9 female and 32 male aged 15-54 years were included in the investigation Nineteen of them had a clinical diagnosis of OPC and 22 a clinical diagnosis of cysts radicularis. All patients had a indication for apicectomy indicating that they had bone defects larger than 20 mm in diameter or destructive alveolus along more than 1/3 of the tooth root.The results are shown on the basis of a clinical follow up and radiographic examination 6 months, 1,2,3 and 4 years after surgery. If, in some cases, a fistula was found during the postoperative followup the treatment was recorded as clinically unsuccessful. Success on the basis of radiographic criteria was also evaluated. First we classified defects into periapical (circumscriptive) and those along the tooth root and than divided the rays into two groups.Unfortunately results for only for 22 patients were abtained and the others were excluded from the investigation because of incomplete follow-up.With regard to total success, according to clinical criterium, 20/22 patients had good clinical diagnosis, i.e. 91%. By radiographic analysis we found complete healing in 13/22 patients or 59%. We also analysed results according to the localization of the periapical change. It was concluded that patients with circumscriptive changes were 88% clinically successful while those with a defect along the tooth root were 93% clinically successful.According to the results of this investigation it can be concluded that OSTEOVIT is a very good resorptive material for filling bone defects and with OSTEOVIT it is possible to widen indication for apicotomy to include cases where more than 1/3 of the tooth has no strong bone base.

4. Ivić-Kardum M, Škunca-Ograjšek D, Katanec D, Sušić M. Application of polyglycolic-polylactic synthetic co-polymer in periodontal intrabony defects. Acta Stomatol Croat. 2000;34(2):207-17.
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   Title in English:	Application of polyglycolic-polylactic synthetic co-polymer in periodontal intrabony defects
   Title in Croatian:	Uporaba poliglikolno-polilaktičnoga sintetskog kopolimera u parodontnim intrakoštanim defektima
   Type of Article:	case report
   MeSH:	BIOCOMPATIBLE MATERIALS POLYMERS ALVEOLAR BONE LOSS + therapy BONE REGENERATION
   Abstract:	The paper presents two cases of clinical application of polyglycolicpolylactic co-polymer Fisiograft. In the first case periodontal abscess and damaged interradicular alveolar bone of tooth 46 was diagnosed. Interradicular damage to the bone was visible after opening the mucoperiosteal flap. Scaling of the root and careful elimination of the inflamed tissue was performed and the defect filled with Fisiograft implant (Ghimas S.p.A - Italy) in the form of gel and powder, moistened with blood and covered with a coronally positioned flap. Postoperatively the patient was advised to rinse her mouth with 0.2% chlorhexidine digluconate solution. The results of the treatment were monitored clinically and radiographically six months after the procedure. Probing the periodontal pockets before the procedure revealed a depth of 8 mm and loss of the level of periodontal attachment of 10 mm on tooth 46. Clinical evaluation six months after the procedure showed a reduction in the depth of the periodontal pocket from 8 to 4 mm and attachment level gain of 5 mm, which amounts to 50% of the original defect. In the second case, after raising the mucoperiosteal flap of tooth 21, an extensive intrabony defect was revealed, which involved several bony walls. After scaling and planing the root we filled the defect with a Fisiograft implant in the form of gel and powder, moistened with blood. Because of the activity of the periodontal pocket we prescribed Amoxicilin tablets 500 mg, 3 times daily for 5 days. Postoperatively, the patient was advised to rinse his mouth with 0.2% chlorhexidine digluconate solution. Six months after the procedure the clinical finding showed reduced depth of the periodontal pocket and gain of attachment level 4 mm, i.e. 44.5% of the original clinical defect. The radiograph showed reduced radiolucency of the alveolar bone of tooth 21, indicating the formation of new supporting alveolar bone. Thus, it can be said that the application of Fisiograft proved to be successful in regeneration of the alveolar intrabony defect. Six months after the procedure the radiograph showed considerably reduced radiolucency and depth of the periodontal pocket was reduced by around 50%.In the presented two cases the application of Fisiograft proved successful in the process of healing alveolar bone, damaged by periodontitis, and it is therefore proposed that this implant is applied in a larger number of subjects and further investigation carried out.

5. Farman AG, Benkovich JA, Farman TT. Dehiscence detection using video prints of enhanced images acquired with a CCD intra-oral detector. Acta Stomatol Croat. 1998;32(4):537-46.
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   Title in English:	Dehiscence detection using video prints of enhanced images acquired with a CCD intra-oral detector
   Title in Croatian:	Otkrivanje dehiscencije uporabom video crteža obogaćenih slika prikupljenih intraoralnim detektorom vrste CCD
   Type of Article:	original scientific paper
   MeSH:	ALVEOLAR PROCESS + pathology ALVEOLAR BONE LOSS + therapy RADIOGRAPHY, DENTAL
   Abstract:	(not available)

6. Karabegović D, Zaklan-Kavić D. [Use of synthograft after tooth apicotomy with extensive bone defect and marginal apical communication to periodontium]. Acta Stomatol Croat. 1990;24(3):175-83.
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   Title in English:	Use of synthograft after tooth apicotomy with extensive bone defect and marginal apical communication to periodontium
   Title in Croatian:	Primjena synthograft-a nakon apikotomije zuba s opsežnim koštanim defektom i marginalno apeksnom komunikacijom parodonta
   Type of Article:	original scientific paper
   MeSH:	APICOECTOMY CALCIUM PHOSPHATES PERIAPICAL DISEASES + therapy TOOTH ROOT + surgery ALVEOLAR BONE LOSS + therapy DENTAL IMPLANTATION
   Abstract:	Synthograft (beta-tricalcium phosphate) is a bioresorptive ceramic material which stimulates osteogenesis after implantation into bone defects and disappears from the site of implantation. In this study, Synthograft was used as a filling in bone defects following apicotomy of teeth with extensive periapical and lateral bone defects along the tooth root involving more than 1/3 of the root, and when an extended periodontal fissure was present in addition. The study included 13 patients with one or more teeth involved. The tricalcium phosphate powder was mixed with patient's own blood and inserted into bone cavities. The patients were followed up during 12 months after surgery by clinical and radiographic control examinations. In all the 13 cases, clinical results were very good, i.e. healing of the wound proceeded without any signs of inflammation, whereas later in the course of follow-up no signs of reaction to the foreign material were observed. Preoperatively loose teeth had gradually become firm and after 12 months were within the limits of physiological motility. Roentgenograms revealed the bone cavities to have filled with newly formed bone, and the periodontal ligament, otherwise lost, was also restored. Results of this study showed the Synthograft implant to be well tolerated by recipients, thus it can be recommended as a filling in extensive bone periapical and lateral defects after tooth apicotomy.