List of Articles by MeSH

PERIODONTAL DISEASES

NOTES:

*Articles are cited according to Uniform Requirements by International Committee of Medical Journal Editors - ICMJE and NLM Style Guide for Authors, Editors and Publishers

Reichert C, Klein M, Kasaj A, Kuhn S, Götz H, Hommel G, Duschner H, Al-Nawas B. Modulation of Osteogenic Cell Morphology by ECM Ligands and Enamel Matrix Derivative. Acta Stomatol Croat. 2009;43(3):188-201.

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Title in English:	Modulation of Osteogenic Cell Morphology by ECM Ligands and Enamel Matrix Derivative
Title in Croatian:	Modulacija morfologije osteogenih stanica pomoću ECM liganada i derivata caklinskog matriksa
Type of Article:	original scientific paper
MeSH:	OSTEOBLASTS EXTRACELLULAR MATRIX ENAMEL MATRIX PROTEINS CYTOSKELETON PERIODONTAL DISEASES
Abstract:	The precondition for successful periodontal regeneration is adequate activation of relevant cell populations like osteogenic cells. Here, cell adhesion and maturation are closely associated with cell morphology and f-actin cytoskeletal organisation. The potential of solitaire extracellular matrix (ECM) components as well as enamel matrix derivative (EMD) to enhance periodontal healing is well documented. Objective: The aim of the study was to test the impact of the ECM proteins collagen type 1 and laminin-1 as well as commercially available EMD on osteogenic cell morphology and cytoskeletal organisation. Material and methods: In an observational study, a total of 2450 osteogenic cells of 5 different cell lines (4 primary ones and 1 commercial one) cultivated on the respective substrates were analysed by 3 independent observers. After staining for the f-actin cytoskeleton and automated CLSM visualisation, cells were assigned to 3 different categories depending on morphological cell attributes (immature vs. intermediate vs. mature). Besides descriptive analysis, a multivariate logistic regression was performed to identify relevant influence parameters on cell morphology and cytoskeletal organisation. Results: The applied solitaire ligands collagen and laminin and especially EMD promoted a mature osteogenic phenotype. Nevertheless, considerable differences between the investigated cell lines could be identified as well. Analysis of cell morphology and cytoskeletal organisation offers a reliable method of acquiring the first hints of biocompatibility and bio-activation on different substrates. Conclusion: Our results highlight the potential of the investigated ligands to support periodontal regeneration by enhancing osteogenic cell attachment and maturation.

Ferreira Lopes MW, Santos Gusmao E, Vasconcelos Alves RD, Cimões R. The Impact of Chronic Periodontitis on Quality of Life in Brazilian Subjects. Acta Stomatol Croat. 2009;43(2):89-98.

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Ognjenović M, Ćurić A. [Chronic Diffuse Apical Periodontitis]. Acta Stomatol Croat. 1997;31(Suppl):335.

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Jorgić-Srdjak K, Plančak D. Odgovor na kritiku prof. J. Aurer-Koželj [in Croatian]. Acta Stomatol Croat. 1996;30(3):233.

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