List of Articles by Author

NOTES:

*This author has been accepted with these names:

Alajbeg, Ivan
Alajbeg, I [Ivan]
Alajbeg, I.

*Articles are cited according to Uniform Requirements by International Committee of Medical Journal Editors - ICMJE and NLM Style Guide for Authors, Editors and Publishers

Richter I, Alajbeg I [Ivan], Vučićević-Boras V, Andabak Rogulj A, Brailo V. Mapping Electrical Impedance Spectra of the Healthy Oral Mucosa: a Pilot Study. Acta Stomatol Croat. 2015;49(4):331-9.

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Alajbeg I [Ivan]. Welcome, Alumni and alumnae! . Acta Stomatol Croat. 2013;47(2):180-.

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Budimir V, Brailo V, Alajbeg I [Ivan], Vučićević-Boras V, Budimir J. Clinical Characteristics of Topical Propolis Induced Oral Lesions. Acta Stomatol Croat. 2012;46(4):297-306.

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Alajbeg I [Ivan], Ivanković S, Jurin M, Pirkić A, Alajbeg-Žilić I, Cekić-Arambašin A. The Effect of Nonaromatic Naphthalane on Mice Oral Planocellular Carcinoma - a Pilot Study. Acta Stomatol Croat. 2004;38(4):267-8.

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Title in English:	The Effect of Nonaromatic Naphthalane on Mice Oral Planocellular Carcinoma - a Pilot Study
Title in Croatian:	Učinak nearomatskog naftalana na mišji oralni planocelularni karcinom - pilot studija
Type of Article:	congress abstract
MeSH:	CARCINOMA, SQUAMOUS CELL
Abstract:	Nonaromatic naphthalane (NAVS) is a specific fraction of Croatian oil, extremely rich in steranes from which the aromatic system is removed. Steranes are attributed with bioactivity similar to steroid hormones, modulators of tumour growth. Encouraged by the results of earlier in vitro and in vivo studies on the inhibitory effect of NAVS on the growth of planocellular carcinoma, we carried out a study on its effect on oral planocellular carcinoma (OPCC) in mice.Aims: 1) To test the validity of the simple experimental model OPCC, 2) to test possible antiproliferative effect of NAVS on the above model by monitoring tumour growth, 3) to test the antineoangiogenic effect of NAVS to explain the possible antiproliferative effect, and to estimate the possibility of crisis reactivity of anti-human immunohistochemical markers with mice tissue. A suspension of 100 μl s 105 SCC VII cell was inoculated intraorally under the buccal mucous membrane in 48 syngeneic C3H mice. Seven days after inoculation the animals were divided in six equal groups and the mice, depending on the group, were intratumorously injected with 100 μl of the following substances: paraffin oil (PO) as a negative control, NAVS (in one group 7 days, and in the second group 14 days, after inoculation of the tumour), 1.25 dihydroxyergotamine (1.25-D3) as a positive control, and a combination of NAVS with 1.25 D3 and PO with 1.25- D3. Tumour growth was monitored weekly by measuring with callipers. The animals were sacrificed 1, 2, 3 and 4 week after application of the tested substance. Histological specimens of explanted tumours were stained with hematoxylin-eozine, and immunohistochemically with anti-CD34 antibodies for estimation of tumour neoangiogenesis. Compared with the PO group, tumour growth and angiogenesis were decreased in the 1.25-D3 and NAVS groups. NAVS probably reduced growth by OPCC inhibition of vascular proliferation, needed for tumour growth.

Hladki A, Alajbeg I[, Cekić-Arambašin A, Alajbeg IŽ. Pilocarpine-Hydrocloride Has a Short-Time Effect on Reducing Xerostomia. Acta Stomatol Croat. 2003;37(3):329-31.

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Title in English:	Pilocarpine-Hydrocloride Has a Short-Time Effect on Reducing Xerostomia
Title in Croatian:	Pilokarpin-hidroklorid ima kratkotrajan učinak u liječenju kserostomije
Type of Article:	congress abstract
MeSH:	XEROSTOMIA + therapy PILOCARPINE + therapeutic use
Abstract:	Xerostomia, i.e. oral dryness, is mainly caused by side effects of medications, immunologic diseases, e.g. Sy. Sjoegren, and radiation treatment for oral and neck cancer. There are variable, although far from satisfactory, treatment options, including that of muscarinic receptor agonist pilocarpine-hydrochloride. Pilocarpine treatment of salivary hypofunction is not yet an established method in croatia.The aim of this preliminary study was to assess the autcome of oral administration of pilocarpin on minor salivary glands and whole saliva production, as well as to monitor possible side effects and patients subjective responses to treatment.Is was a single blind-placebo controlled trial. Ten patients suffering from xerostomia underwent this trial. Patients with cardiac or pulmonary diseases were excludet, as well as those that did not show any increase in salivary flow rate after administration of ascorbic acid solution (chemical stimulant) at inclusion testing one week prior to the experiment. The experiment comprised 7 repeated measurements in time intervals of 15-30 min., from the baseline up to 2 h after single oral administration of 5 mg of pilocarpine hydrochloride ( 5 drops of slution, Pilokarpin 2%, pliva, Croatia). The flow rate of minor salivary glands was measured on the lower lip and palate by means of Periotron (Oraflow Inc., Plainview, USA) and whole saliva was collected in calibrated test tubes . A simple questionnaire was filled in to record patients subjective perception of treatment. The same procedure was repeated one week later, when dexpanthenol drops (DPanthenol, Ljekarne Zagreb, Croatia) were used as placebo instead of pilocarpine.Pilocarpine increased salivary output and gave symptomatic relief in every patient. The differences in salivary output were significant both compared to baseline and to placebo controls (p = 0,01). There were no side effects during the trial, either after administration of pilocarpine; or placebo. After increasing salivary flow rate the action of pilocarpine decrease in time, which was recordable during the observation session.Respecting possible contraindications and side effects, according to our finding pilocarpine should be regulary used in treatment of xerostomia.

Alajbeg I[, Hladki N, Cekić-Arambašin A, Alajbeg IŽ. Periotron as a Modern Sialometric Method in Xerostomia Diagnosis and Treatment Monitoring. Acta Stomatol Croat. 2003;37(3):296-7.

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Title in English:	Periotron as a Modern Sialometric Method in Xerostomia Diagnosis and Treatment Monitoring
Title in Croatian:	Periotron: Suvremena sijalografijska metoda u dijagnostici i u nadzoru liječenja kserosromije
Type of Article:	congress abstract
MeSH:	XEROSTOMIA + diagnosis
Abstract:	The Periotron micro-moisture meter (Oraflow, Plainview, USA) is an electronic instrument that has been designed for gingival vrevicular fluid (GCF), periodontal pocket fluid (PPF), salivary flow and saliva thickness measurments, by using a variety of paper collection strips. Collection strips (Periopaper strips, PerioCol strips, Sialopaper strips) are applied to the oral tissues of interest for a certain period of time, after which the are inserted between Periotron electrodes. The special insulation coating on the electrodes enables them to work as two plates of a capacitor, being able to measure submicroliter quantities of oral fluids. Periotron displays the numerical output on LCD. By inputting data obtained during prior calibration process into Periotron professional software for Windows, we design a standard curve, from which we interpolate actual fluid volume. We have designed a single blind placebo controlled study to evaluate possible presence of long-term effect of pilocarpine-hydrocloride (PHC) on salivary flow rate in patients with xerostomia. 12 patients suffering from xerostomia underwent this trial. We used strict inclusion criteria regarding the possible side effects. Six patients were instructed to self-administer 5 mh of PHC (5 drops of solution, Pilokarpin 2%, pliva Zagreb, Croatia), three times a day, for 7 days. Another 6 patients (placebo group) were instructed to take 5 dexapanthenol drops (D panthenol, Ljekarne Zagreb, Zagreb, croatia), 3 times a day for 7 weeks. The flow rate of minor salivary glands was measured on the lower lip and palate by means of Periotron and whole saliva was collected in calibrated test tubes. mesurements were repeated once a week. Each patient filled in an extensive Oral Health Impact Profile questionnaire (OHIP) at te baseline and after completion of PHC treatment to monitor oral health influence on patients lives. After 7 weeks of treatment the placebo group was swiched to PHC, but there no apparent need for switching pilocarpine group to placebo, because we found no improvement in salivary flow rate after 7 weeks of treatment. in the group previously taking placebo, there was also no improvement in salivary flow rate after taking PHC. OHIP findings were calculated and showed no statistically significnt improvement after 7 weeks of PHC administration. One patient from the pilocarpine group and one from palcebo group ( while taking placebo) reported side effects and discontinuited the trial. oral administration of PHC does not seem to produce log-term salivary flow rate increase, but rther immediate and shortr lasting improvement. Judging by Periotron and whole saliva scores, our results showed that PHC is not able to “cure” xerostomia after prolonged administration, i.e. there is no residual effect in salivary gland simulation once the drug is discontinued and eliminated.

Alajbeg I[, Cekić-Arambašin A, Alajbeg A, Ivanković S, Jurin M, Krnjević-Pezić G, Vržogić P, Dobrić I. Non-Aromatic Naphthalane: a Future Remedy For Oral Mucosal Lesions. Acta Stomatol Croat. 2003;37(3):295-6.

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Title in English:	Non-Aromatic Naphthalane: a Future Remedy For Oral Mucosal Lesions
Title in Croatian:	Nearomatski naftalan - budući lijek za oralne lezije
Type of Article:	congress abstract
MeSH:	MOUTH DISEASES + therapy
Abstract:	The purpose of this lecture is to summarize data obtained from several experiments conducted by authors, regarding the composition of special Croatian petrol fraction reffered to as “Non Aromatic- Very rich in Steranes” (NAVS) naphthalane, as well as its potent-inflammatory and cellular growth controlling effect. NAVS is derived from ordinary brown naphthalane, particulaly rich in steranes, that has been famous for decades in the treatment of psoriasis vulgaris (Naftalan, Ivanić Grad, Croatia). NAVS was prepared by removing virtually all of its original polycyclic aromatic content (some of them are carcinogenic), which resulted in completely colourless transparent oil with a pleasant scent. Steranes were preserved and concentrated during the de-aromatisation process, as was proven by means of GC and GC-MS. These geogenic steranes have molecular skeletons analogous to bioactive compounds, such as corticosteroids and vitamin D. Due to these structure similarities, we can explain the beneficial affects in treating psoriatic patients with NAVS, which yielded promising results. NAVS treatment did not affect either haematological or biochemical findings. Further studies established In vitro dose dependant inhibition of planocellular carcinoma (SCC VII) cell proliferation, withhout interfering with nonmalignant fibroblast (L929) cells, thus showing selectivity in cell proliferation control. In vivo results showed marked delay in tumour growth. A rationale for that, besides cell proliferation control, authors see also in the antineoangiogenetic activity of NAVS (similar to vitamin D), wich is yet to bi proved through immunohistochemical studies. Future studies are planned and oral planocellular carsinoma animal models are being developed in order to introduce NAVS in the treatment of different conditions of oral mucosa, because the preparation is not only effective, but also highly applicable in oral tissues, due to its superior organoleptic properties.

Alajbeg I [Iva], Valentić-Peruzović M, Alajbeg I [Ivan], Illeš D, Knezović-Zlatarić D, Katunarić M. Electromiographic Evaluation of Masticatory Muscle Activity in Patients with Temporomandibular Dysfunction. Acta Stomatol Croat. 2003;37(2):131-45.

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Title in English:	Electromiographic Evaluation of Masticatory Muscle Activity in Patients with Temporomandibular Dysfunction
Title in Croatian:	Elektromiografsko ispitivanje aktivnosti žvačnih mišića u ispitanika s temporomandibularnom disfunkcijom
Type of Article:	preliminary report
MeSH:	ELECTROMYOGRAPHY TEMPOROMANDIBULAR JOINT DISORDERS + diagnosis MASTICATORY MUSCLES + physiology
Abstract:	The term temporomandibular dysfunction (TMD) encompasses a group of disorders of the masticatory muscles and temporomandibular joints. Major precipitating factors are occlusal, traumatic, psychosocial and systemic factors. The aim of this investigation was to determine possible altered muscular function in patients with TMD, as well as to determine the need for EMG application in TMD diagnosis. Forty young adults participated in this study: 13 subjects with signs and symptoms of TMD and 27 asymptomatic subjects, sex and age matched. Surface EMG recordings were obtained from left and right anterior temporal muscle, left and right masseter muscle and from left and right digastric muscle in eight mandibular positions. Right side to left side ratio of examined muscles myoelectrical signals in lateral occlusal and maximal lateral positions for the asymptomatic group showed significantly higher activity of the working side anterior temporal muscle (p<0.05). In the group of patients with TMD, regarding the same muscle, statistically significant differences were found only in the left occlusal and left maximal lateral position (p<0.05), at which greater activity was found for the working side temporal muscle. In the same positions of the right side no significant differences in anterior temporal muscle activity were found (p>0.05). Comparison of myoelectrical signals in the position of maximal intercuspation of teeth between the patients and the controls, showed significantly higher activity in right and left masseter muscle at 50% MVC (p<0.05) in the symptomatic group.Results of this investigation showed the presence of altered masticatory muscle activity in TMD patients and confirmed the use of electromyography in TMD diagnosis.

Topić B, Alajbeg I[, Vučićević-Boras V, Alajbeg ZI, Cekić-Arambašin A. The Prevalence of Candida Albicans in Institutionalized Geriatric Denture Wearers. Acta Stomatol Croat. 2002;36(3):345.

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Alajbeg IZ, Valentić-Peruzović M, Illeš D, Alajbeg I[, Knezović-Zlatarić D. Electromyographic Evaluation of the Influence of Denture Adhesive on Retention and Stability of Complete Dentures. Acta Stomatol Croat. 2002;36(3):334-5.

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Title in English:	Electromyographic Evaluation of the Influence of Denture Adhesive on Retention and Stability of Complete Dentures
Title in Croatian:	nema
Type of Article:	congress abstract
MeSH:	ELECTROMYOGRAPHY DENTURE RETENTION
Abstract:	Improving retention and stability of complete dentures is of considerable interest in prosthetic dentistry. Approaches to this problem over the years have included overdentures, implants and denture adhesives. Although denture adhesives are widely used, there are few quantitative data on the effects of an adhesive on denture retention and stability during normal functional activities. The purpose of this investigation was to study the influence of denture adhesive on the surface EMG activity of the masticatory muscles in a sample of complete denture wearers. In this study 6 denture wearers were investigated. Surface EMG recordings were obtained from left and right anterior temporal and masseter muscle and from the sub-mandibular group in the region of the anterior belly of the digastric muscle on the left and right side. Data were recorded during standardized jaw positions that included clenching in the position of maximal intercuspation of teeth (at 100%, 50% and 25% of the maximum activity), lateral eccentric positions, maximal lateraleccentric positions, protrusion, maximal protrusion and wide opening. The results demonstrated higher digastric muscle activity in protrusion with the teeth at an edge-toedge position after the use of adhesive (p<0.05). In the laterotrusive position, after the use of adhesive, the working side elevator muscles activities increased, although without any statistical significance (p>0.05). This investigation demonstrated that patients were able to produce greaterlevels of muscle activity in protrusive and laterotrusive positions with the use of adhesive.

Vučićević-Boras V, Cekić-Arambašin A, Alajbeg I [Ivan], Biočina-Lukenda D, Blažić-Potočki Z, Ognjenović M. Dentists' knowledge of HIV infection. Acta Stomatol Croat. 2001;35(1):9-18.

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Vučićević-Boras V, Cekić-Arambašin A, Alajbeg I [Ivan], Biočina-Lukenda D. Knowledge of fifth year students on HIV infection. Acta Stomatol Croat. 1999;33(4):401-9.

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Hemerich L, Juričić-Čulina I, Mravak-Stipetić M, Alajbeg I, Jerolimov V. Djelotvornost Octenisepta na candidu albicans kod bolesnika sa stomatitis prothetica [in Croatian]. Acta Stomatol Croat. 1998;32(Suppl):166.

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Alajbeg I [Ivan], Jerolimov V, Carek V, Baučić I, Pandurić J. [Comparative investigation of residual monomer in polyacrylates by high resolution gas chromatography and infrared spectrophotometry methods]. Acta Stomatol Croat. 1997;31(4):353-8.

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Alajbeg I [Ivan], Carek V, Jerolimov V, Urlić V, Baučić I. [Investigation of residual monomer in microwave - and heat-polymerized acrylates by a procedure of infrared spectrophotometry]. Acta Stomatol Croat. 1997;31(3):201-6.

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