List of Articles by Author

1. Prica D, Galić N, Želježić D, Prica A, Šegović S. Genotoxic Potential of Dentin Bonding Agents. Acta Stomatol Croat. 2007;41(2):104-14.
    [details]
    [close]
   Full Text

   Title in English:	Genotoxic Potential of Dentin Bonding Agents
   Title in Croatian:	Genotoksični potencijal dentinskih adheziva
   Type of Article:	original scientific paper
   MeSH:	DENTIN-BONDING AGENTS MUTAGENS + toxicity CHROMOSOME ABERRATIONS
   Abstract:	The aim of this study was to examine the genotoxic activity of five dentin bonding agents: Adper Single Bond, Adper Single Bond 2, Prompt L-pop, Excite and Opti-Bond Solo Plus. This in vitro study was performed on human lymphocytes from peripheral blood, and the concentrations of dentin bonding agents tested were 0.2, 0.5 i 5 μg/ml, and elution times tested were 1 hour, 24 hours and 5 days. Genotoxicity testing was done using the Structural chromosomal aberration analysis cytogenic method , which determined the complete number of chromosome breaks, chromatide breaks and acentric fragments. The results showed genotoxicity of Opti-Bond Solo Plus in the 0.2 μg/ml concentration after a 24-hour elution period, then OptiBond Solo Plus in the 0.5 μg/ml concentration after a 1 hour elution period and OptiBond Solo Plus, Adper Single Bond 2 and Excite in the 0.5 μg/ml concentration after a 1 day elution period. In the 5 μg/ml concentration after 1 hour of elution, genotoxic potential was observed in cultures with OptiBond Solo Plus, Excite, Adper Single Bond 2 and Adper Single Bond, while all dentin bonding agents showed genotoxicity at that highest concentration but after 1 day of elution. From the results it is obvious that genotoxicity increases with the concentration of the dentin bonding agent, and decreases over time. The highest genotoxicity was observed after a 24-hour-elution period.