List of Articles by Author

NOTES:

*This author has been accepted with these names:

Brajdić, Davor
Brajdić, D

*Articles are cited according to Uniform Requirements by International Committee of Medical Journal Editors - ICMJE and NLM Style Guide for Authors, Editors and Publishers

Brajdić D, Macan D. Implants in Patients on Bisphosphonate Therapy: Yes, No, When?. Acta Stomatol Croat. 2008;42(1):105.

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Title in English:	Implants in Patients on Bisphosphonate Therapy: Yes, No, When?
Title in Croatian:	Implantati u bolesnika liječenih bifosfonatima: da, ne i kada?
Type of Article:	congress abstract
MeSH:	DIPHOSPHONATES OSTEONECROSIS JAW DISEASES
Abstract:	Bisphosphonates are used in therapy of Paget disease, for treatment and prevention of postmenopausal, senile or corticosteroid-induced osteoporosis and hypercalcemia caused by osteolysis in a number of malignant diseases such as multiple myeloma, lung, prostate or breast cancer. Despite numerous side-effects, according to the latest studies, this drug group is promising in regards of increase of therapeutical indications. Their influence on the bone can be contradictory, as side-effects that are a consequence of their antiangiogenetic and apoptotic action on keratinocytes. Osteoclast apoptosis on the molecular level reduces bone restructuring. Bisphosphonate molecules are incorporated in hydroxilapatite matrix that leads to the changes in bone microstructure, slowing of growth and degradation of bone minerals. Osteoblastic activity remains undisturbed so there is an increase of bone mass. These changes occur in all bones, but due to the specific good blood vessel network of the jaw bones, their increased daily activity and presence of teeth, they are prone to the accumulation of higher drug concentration, and therefore higher incidence of side-effects. Osteonecrosis is mostly a consequence of traumatization of soft and bone tissue, either by a foreign body, and prosthetic restoration, or a dental procedure, mostly tooth extraction. Avascular necrosis and osteonecrosis as consequences are higher in more potent bisphosphonates that are taken parenterally – Aredia (pamidronate-disodium), Zometa (zolendronate) – and lower in peroral prescriptions – Pleostat (ethidronatedisodium), Fosamax (alendronate-sodium), Actonel (risedronate) and Bonefos (chlodronate-disodium). The risk is in correlation with the presence of nitrous chains in the drug, cumulative effects of the dosis, duration of therapy, presence of medical and dental comorbidity, chemotherapy and invasive dental procedures. Invasive dental procedures should be performed at least one month before start of the bisphosphonate therapy, and it is recommended to avoid any dental treatment during therapy, unless there are certain indications for any procedure according to type or duration of bisphosphonate therapy.

Brajdić D, Macan D. Alveolar Bone Reconstruction for Implant Placement in Anterior Maxilla. Acta Stomatol Croat. 2008;42(1):99-100.

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Title in English:	Alveolar Bone Reconstruction for Implant Placement in Anterior Maxilla
Title in Croatian:	Rekonstrukcija dijela alveolarnog grebena za postavu dentalnih implantata u prednjoj maksili
Type of Article:	congress abstract
MeSH:	DENTAL IMPLANTATION, ENDOSSEOUS DENTAL IMPLANTS MAXILLA ALVEOLAR BONE LOSS TRANSPLANTATION, AUTOLOGOUS BONE REGENERATION
Abstract:	Reconstruction of demanding areas represent a particular clinical challenge in implant dentistry. These are mostly atrophic regions with sinus recesses, as well as the region close to the nasal cavity in the anterior part of the maxilla. In mandible, the vertical atrophy laterally leads to the inability to place implants to the proximity of the alveolar nerve in one procedure. Horizontal atrophy can cause inability to place implants, even when the vertical dimension is satisfactory. A combination of these findings is especially demanding in the anterior parts of maxilla, due to the functional and esthetic requirements of prosthetic reconstructions. We show three cases of extreme resorption in anterior maxilla, where one teeth was missing. First is a case of horizontal resorption with two cortical plates joined together and the crest width of 3 mm. By expanding the crest we were able to place an implant (Ankylos®, Friadent, Germany) in the same procedure. Second case was extensive resorption of the vestibular socket wall, where we were able to regain bone by combining xenogene (Bio- Oss® - Geistlich Biomaterials, Switzerland) and autologous bone material and by covering it with a resorbable membrane (Bio-Gide® - Geistlich Biomaterials, Switzerland). After 4 months of healing an implant was placed in the regenerated bone (Ankylos), with satisfactory primary stability. Third case was a situation of extenstive horizontal and vertical resorption, similar to the first case. By using resorbable membrane on both sides of the defect and a mixture of xenogenous and autologous bone material, and a block transplant fixated with a screw, we obtained acceptable bakterijbone dimension for implant placement after 4 months of healing.

Brajdić D, Macan D. Dental Implants in Medically Compromised Patients. Acta Stomatol Croat. 2005;39(3):252-3.

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Title in English:	Dental Implants in Medically Compromised Patients
Title in Croatian:	Zubni usadci u medicinski kompromitiranih pacijenata
Type of Article:	congress abstract
MeSH:	DENTAL IMPLANTS
Abstract:	Today, therapy of partial or complete edentulousness by dental implants plays an increasingly significant role in the oral rehabilitation of patients, and is expected in the future to further increase in accordance with the development of other medical fields. However, all ardent advocates of dental implants and implantological enthusiasts, must know how to control and direct their activity through the prism of physiological and pathophysiological events in each patient, regardless of whether he/she is entirely healthy or effected by some pathological disorder, having in view his/her general and oral health.Many medically compromised patients seek implantological therapy for the purpose of their oral rehabilitation. We are of the opinion that today guidelines for pre and post implantological therapy of such patients have still not been entirely clarified, and consequently are not completely clear to dental practitioners and oral surgeons. The purpose of our presentation is to give a critical assessment of opinions and literature to date, and to give clear and scientifically founded guidelines for implantological therapy in such patients.Current knowledge will be discussed on the influence of the most frequent systemic and local diseases, impairments and conditions on therapy by dental implants. They include disorders and changes in bone metabolism (osteomalacia, osteopenia, osteoporosis, osteoradionecrosis) and ageing of the patient - diabetes mellitus, xerostomia, conditions in the area of the jaw following irradiation, ectodermal dysplasia, cardiopulmonary disease, smoking, hypothyrosis, autoimmune diseases (sclerodermia, Chron’s disease), Parkinson’s disease and haematological diseases (anaemia, leukaemia, haemostasis disorders....) and conditions caused by various medications (corticosteroids, cytostatics, phenitoin, blockers of calcium canals....).Specific pathophysiological aspects of the influence of the aforementioned conditions on the process of osseointegration and their possible effect on dental implants, will be explained in detail for the purpose of their possible and more simple application in the daily practice of every clinician engaged in dental implantology. Accordingly, we will present our guidelines for pre and post surgical treatment of implanted, medically compromised patients.

Bergovec L, Brajdić D, Macan D. Mucocele. Acta Stomatol Croat. 2004;38(4):294-5.

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Title in English:	Mucocele
Title in Croatian:	Mukokele
Type of Article:	congress abstract
MeSH:	MUCOCELE
Abstract:	In the Out-Patient Department of Oral Surgery we daily come across salivary cysts which we treat surgically - by scaling or marsupialisation.We considered that it would be helpful to analyse these changes clinically, histopathologically and pathogenetically.There are two types of salivary cysts: retention cysts (histologically a salivary gland with dilated secretory canals lined with large cells with honeycomb cytoplasm) and extravasation cysts (a hollow mass filled with cellular detritus and bacteria, coated with cylindrical and stratified epithelia).Mucocele are coated with a lining of granulation tissue and contain eozinophyllic hyaline material. They occur throughout the whole of the mucous membrane of the oral cavity, although the majority are on the lower lip. They most frequently occur because of mechanical injury to the secretory canals of the small salivary glands and retention. They are approximately 1.5 cm in diameter. They cause slight cyanosis of the area and bluish-white surface which occurs as a result of the narrowing of the blood vessels and thin walls of the mucocele.We retrospectively analysed histopathological findings with a clinical diagnosis “mucocele” during the period 1 January 1995 to 31 December 2000. During that period a total number of 9047 people were operated. Of 1358 findings sent for histopathological analysis (PHD), 89 were clinically diagnosed as mucocele. Of these 89 lesions in only 72 cases was the diagnosis of mucocele confirmed histopathologically. Differences in gender did not essentially have an effect on the occurrence of mucocele, and according to the results of the investigation we found that although mucocele occurs in all age groups, it is more frequent in younger people during the second and third decade of life. In our investigation mucocele were largely located on the lower lip, 83.3%. Other mucocele were located in the sublingual space, on the mucous membrane of the cheek and in the vestibulum of the oral cavity. According to the histopathological description we concluded that 23 mucocele were of retention type and two extravasation lesions.

Brajdić D, Macan D. Treatment of Acute Odontogenic Inflamation in National Health Care. Acta Stomatol Croat. 2004;38(4):291-2.

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Title in English:	Treatment of Acute Odontogenic Inflamation in National Health Care
Title in Croatian:	Liječenje akutne odontogene upale u primarnoj zdravstvenoj zaštiti
Type of Article:	congress abstract
MeSH:	INFECTION DELIVERY OF HEALTH CARE
Abstract:	Acute odontogenic inflammation is the most frequent disease because of which patients come to the Out-Patient Clinic of Oral Surgery. In the majority of cases help can, and should, be ensured in the dental surgeries of National Health clinics.The object of our investigation was to determine how and in what way, some dentists treat acute odontogenic infections and why they refer patients with acute odontogenic swelling to the Out-Patient Clinic of Oral Surgery.We arrived at the following data by prospectively completing a questionnaire for 38 patients, selected at random, who had come to the Out-Patient Clinic of Oral Surgery, Clinic for Maxillofacial and Oral Surgery, University Hospital Dubrava, because of swellings of odontogenic aetiology.Of these patients, 79% were referred by dentists, 13% general practitioners and 8% came on their own initiative. Two-thirds of the patients were referred by female dentists, mean age 38 years, while the remaining patients were referred by male dentists, mean age 41 years. Female dentists most frequently prescribe only antibiotics, 60% in our questionnaire, and 20% refer patients without any therapy at all or after trepanation and prescribed antibiotics. In the same way in 40% of cases male dentists refer patients without any therapy at all or only prescribed antibiotics, and only 20% perform trepanation and prescribe antibiotics. The oldest dentists, mean age 43 years, do not carry out any therapy at all, and antibiotics are only prescribed by those aged around 39 years, and trepanation of the tooth and antibiotics are prescribed by the youngest dentists, mean age 34 years. The most frequent explanation for referring patients to our Out-Patient Department are: “cannot do any work because of the swelling”, allergy to medications, “cannot give an injection because of the swelling” and “does not have the instruments”. One third of the patients did not receive any kind of therapy prior to being referred to our Department. Trepanation and antibiotics were performed in only 18% of cases. In this investigation the most frequent method of treatment was the application of antibiotics (53%). Not one intraoral incision was performed prior to being referred to our Department. We performed intraoral incision in two-thirds of the patients and only 13% were justifiably referred to our Department because extraoral incision had been performed, i.e. three in out-patient departments and two in hospital.The results of this questionnaire indicate the unacceptable attitude of some dentists towards treatment of acute odontogenic swellings. Thus, there is clearly a need for more intense undergraduate teaching and permanent training of the national health dentist on the problem of treating acute odontogenic inflammation, and for raising the quality of national health dental care with the object of reducing the occurrence of odontogenic inflammations and their complications, and the need for hospitalisation of such patients.

Azinović Z, Azinović I, Krznarić O, Brajdić D. Number of the Dentinal Tubules as a Function of Cavity Dept. Acta Stomatol Croat. 2003;37(3):304-5.

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