List of Articles by Author
- Knezović Zlatarić D, Koršić M, Filipović-Zore I. Jaw Osteonecrosis in Patients Treated by Bisphosphonates. Acta Stomatol Croat. 2008;42(1):104-5.
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Title in English: |
Jaw Osteonecrosis in Patients Treated by Bisphosphonates |
Title in Croatian: |
Pojavnost osteonekroze čeljusti povezane s liječenjem bisfosfonatima |
Type of Article: |
congress abstract |
MeSH: |
DIPHOSPHONATES OSTEONECROSIS JAW DISEASES |
Abstract: |
Bisphosphonates, drugs that influence bone structure, are used in treatment of a number of bone diseases, from osteoporosis to malignomas with subsequent osteolysis. Recently bisphosphonates have been linked to jaw osteonecrosis. These changes are more frequent in patients receiving parenteral bisphosphonates (zolendronate and pamidronate), while in others, such as alendronate, they are not so frequent. It has been shown that the duration of therapy increases the risk of jaw osteonecrosis.Osteonecrosis of the jaw, as susceptible regions, is explained by the fact that the bone is under constant stress during chewing, as well as under constant invasion with oral microorganisms. It has been suggested that in treating of jaw osteonecrosis one should combine antibiotics with oral surgical procedures. Since the knowledge on this correlation is limited, it has been recommended that patients with increased risk of osteonecrosis should perform preventive measures such as good oral hygiene, adaptation of removable prosthetic devices, restauration of carious lesions and endodontic treatment. Dental examination is necessary before commencing bisphosphonate therapy. We present a case of an elderly male patient with advanced osteonecrosis and subsequent vertebral compression fractures. |
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