List of Articles by Author

1. Walter C, Grötz KA, Kašaj A, Albricht S, Schmidt M, Nauroth B, Al-Nawas B. Prevalence of bisphosphonate associated osteonecrosis of the jaws in breast cancer patients. Acta Stomatol Croat. 2009;43(4):271-8.
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   Title in English:	Prevalence of bisphosphonate associated osteonecrosis of the jaws in breast cancer patients
   Title in Croatian:	Prevalencija osteonekroze čeljusti povezane s bifosfonatima kod pacijenata s rakom dojke
   Type of Article:	original scientific paper
   MeSH:	DIPHOSPHONATES OSTEONECROSIS JAW DISEASES ORAL HYGIENE BREAST CANCER
   Abstract:	Objective: To evaluate the prevalence of Bisphosphonate-associated-osteonecrosis-of-the-jaws (BP-ONJ) and protective factors of BP-ONJ-development in breast cancer patients with osseous metastasis and bisphosphonate therapy using systematical dental oral examinations. Material and Methods: A cross-sectional-study was conducted in the Department for Gynecology in Mainz, Germany. All breast cancer patients (n=51) treated with bisphosphonate in the time span from 07/2006 to 09/2007 were recruited. Primary outcome was the development of BP-ONJ and the detection of possible additional trigger factors for the development of BP-ONJ, as well as possible factors for avoiding BP-ONJ. Results: Only 1 out of 51 patients developed BP-ONJ (2.0%). A tooth extraction could be identified as an additional trigger factor. The overall dental hygiene of this patient clientele was above average. Conclusion: Compared to other alignant diseases, BP-ONJ in breast cancer patients does not appear as often. The underlying disease might be of importance in the development of BP-ONJ. A good dental hygiene might be a protective factor.

2. Reichert C, Klein M, Kasaj A, Kuhn S, Götz H, Hommel G, Duschner H, Al-Nawas B. Modulation of Osteogenic Cell Morphology by ECM Ligands and Enamel Matrix Derivative. Acta Stomatol Croat. 2009;43(3):188-201.
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   Title in English:	Modulation of Osteogenic Cell Morphology by ECM Ligands and Enamel Matrix Derivative
   Title in Croatian:	Modulacija morfologije osteogenih stanica pomoću ECM liganada i derivata caklinskog matriksa
   Type of Article:	original scientific paper
   MeSH:	OSTEOBLASTS EXTRACELLULAR MATRIX ENAMEL MATRIX PROTEINS CYTOSKELETON PERIODONTAL DISEASES
   Abstract:	The precondition for successful periodontal regeneration is adequate activation of relevant cell populations like osteogenic cells. Here, cell adhesion and maturation are closely associated with cell morphology and f-actin cytoskeletal organisation. The potential of solitaire extracellular matrix (ECM) components as well as enamel matrix derivative (EMD) to enhance periodontal healing is well documented. Objective: The aim of the study was to test the impact of the ECM proteins collagen type 1 and laminin-1 as well as commercially available EMD on osteogenic cell morphology and cytoskeletal organisation. Material and methods: In an observational study, a total of 2450 osteogenic cells of 5 different cell lines (4 primary ones and 1 commercial one) cultivated on the respective substrates were analysed by 3 independent observers. After staining for the f-actin cytoskeleton and automated CLSM visualisation, cells were assigned to 3 different categories depending on morphological cell attributes (immature vs. intermediate vs. mature). Besides descriptive analysis, a multivariate logistic regression was performed to identify relevant influence parameters on cell morphology and cytoskeletal organisation. Results: The applied solitaire ligands collagen and laminin and especially EMD promoted a mature osteogenic phenotype. Nevertheless, considerable differences between the investigated cell lines could be identified as well. Analysis of cell morphology and cytoskeletal organisation offers a reliable method of acquiring the first hints of biocompatibility and bio-activation on different substrates. Conclusion: Our results highlight the potential of the investigated ligands to support periodontal regeneration by enhancing osteogenic cell attachment and maturation.

3. Sculean A, Kašaj A, Willershausen B. The Application of Enamel Matrix Proteine Derivative (Emdogain) in Regenaerative Periodontal Therapy: Which Applications are Evidence-Based. Acta Stomatol Croat. 2004;38(3):215-28.
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   Title in English:	The Application of Enamel Matrix Proteine Derivative (Emdogain) in Regenaerative Periodontal Therapy: Which Applications are Evidence-Based
   Title in Croatian:	Primjena proteinskog derivata matriksa cakline (Emdogain) pri regenerativnom liječenju parodonta: koji se oblici primjene zasnivaju na dokazima
   Type of Article:	professional paper
   MeSH:	PERIODONTAL DISEASES + therapy CEMENTOGENESIS REGENERATION
   Abstract:	The goal of regenerative periodontal therapy is the reconstitution of the lost periodontal structures (i.e. the new formation of root cementum, periodontal ligament and alveolar bone). Results from basic research have pointed to the important role of the enamel matrix protein derivative (EMD) in periodontal wound healing. Histological results of experiments in animals and of human case reports have shown that treatment with EMD promotes periodontal regeneration. Moreover, clinical studies have indicated that treatment with EMD positively influences periodontal wound healing in humans. The goal of the current overview is to present, based on the existing evidence, the clinical indications for regenerative therapy with EMD.