List of Articles by Author

1. Macan D, Uglešić V, Knežević P, Potočki K, Šutić I, Jokić D, Keser I. Clinical Use of Bone Morphogenetic Protein rhBMP-7 in Implantology. Acta Stomatol Croat. 2008;42(1):100.
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   Title in English:	Clinical Use of Bone Morphogenetic Protein rhBMP-7 in Implantology
   Title in Croatian:	Klinička primjena koštanog morfogenetskog proteina rhBMP-7 u implantologiji
   Type of Article:	congress abstract
   MeSH:	BONE MORPHOGENETIC PROTEINS BONE REGENERATION DENTAL IMPLANTATION, ENDOSSEOUS MANDIBLE TRANSPLANTATION, AUTOLOGOUS
   Abstract:	Bone morphogenetic protein (BMP) is the most promising osteoinductive substance and has demonstrated the ability to stimulate bone regeneration. Several animal studies confirmed that the application of bone morphogenetic proteins caused a more rapid and enhanced osseointegration of simultaneously placed implants when compared to the bone substitute alone. To our knowledge, only two case reports presented clinical use of BMP-7 in maxillofacial surgery (maxillary sinus floor elevation; Le Fort I osteotomy and advancement).We present patient with recurrent ameloblastoma treated by segmental osteotomy of the mandible. The bone defect (6 cm length) was reconstructed by autogenous iliac crest bone grafts using BMP-7 (Stryker Biotech, USA). Radiographic evidence of new bone formation was seen at 9 months, postoperatively. A biopsy was taken at 9 months demonstrated viable new bone formation. A year after the reconstruction we have inserted three dental implants (Ankylos ®, Friadent, Germany). One implant failed, and two years after the insertion we have loaded two implants with ceramic bridge. Follow-up period is two years. To our knowledge, this is the first described case of dental implants inserted in resected mandible reconstructed by bone graft using bone morphogenetic protein. The problem of BMP-7 dosage and overgrowth of the graft should be discussed. Although this case has shown encouraging results, long-term results and the predictability of nthis type of reconstruction in humans are still unknown.

2. Knežević B, Knežević P, Uglešić V, Zubčić V. Facial Bite Wound. Acta Stomatol Croat. 2006;40(1):83-8.
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   Title in English:	Facial Bite Wound
   Title in Croatian:	Ugrizna rana lica
   Type of Article:	case report
   MeSH:	BITES AND STINGS WOUND INFECTION BACTERIAL INFECTIONS
   Abstract:	Bite wounds are one of the most frequent human traumas. Most frequently it is the dog bites (more than 80%), cats, and humans. Great percentage of these traumas is located on the face, especially in children. Most frequently isolated bacteria in the wounds are aerobes and anaerobes from the oral flora of the attacker and aerobes from the victim’s skin. The treatment of facial bite wounds has its characteristics when compared to other body parts, in that they are primarily sutured. Due to the excellent vascularity the complications are rare, but if they occur, they can be life threatening. This article reports an infection of a facial bite wound caused by horse bite and the treatment of subsequent complications.

3. Jurić M, Uglešić V, Knežević P, Filipović-Zore I. Treatment Costs for the Patient with Head and Neck Tumours. Acta Stomatol Croat. 2005;39(1):67-76.
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   Title in English:	Treatment Costs for the Patient with Head and Neck Tumours
   Title in Croatian:	Cijena liječenja bolesnika s tumorima glave i vrata
   Type of Article:	professional paper
   MeSH:	HEAD AND NECK NEOPLASMS + economics
   Abstract:	Surgery of head and neck tumours is complex and unequivocally expensive. There have been very few investigations to date in the world on the cost of treatment of this group of patients, and in Croatia not one. The aim of the present study was to determine the cost of treating patients with head and neck tumours, its structure and factors which have a significant influence on it. The study included 248 patients, treated in the Clinic of Maxillofacial Surgery in Zagreb during the period 1995 - 1996. The cost of treatment is presented as the total cost of hospital expenses, diagnostics, operations, anaesthesia and radiotherapy, and its dependence on all factors tested which we assumed to have a significant effect on it.The average cost of treatment for the patient with head and neck tumours is 17,297 kn. The duration of hospitalisation, type of ablation and reconstructive surgical procedure has the greatest influence on the cost of treatment. Thus, intervention in this segment would enable the greatest savings. As the duration of treatment and type of therapy is decided by the physician, the planning and realisation of cheaper treatment is the responsibility of the physician.

4. Uglešić V, Jokić D, Knežević P, Gašparović S. Orthognathic Surgery - Functional or Aesthetic Surgery. Acta Stomatol Croat. 2004;38(4):265.
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   Title in English:	Orthognathic Surgery - Functional or Aesthetic Surgery
   Title in Croatian:	Ortognatska kirurgija, funkcionalan ili estetski postupak
   Type of Article:	congress abstract
   MeSH:	ORTHODONTICS + methods
   Abstract:	Orthognathic surgery can be a functional and aesthetic operation. Patients, orthodontists and our indications for surgery will be presented.Preoperative planning, course of therapy, results and complications for genioplasty, mandibular development and setback, maxillary development and bimaxillary operations will be discussed.

5. Košutić D, Uglešić V, Knežević P, Jurić M, Manojlović S. Ossifying Fibroma of the Orbit. Acta Stomatol Croat. 2004;38(3):229-35.
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   Title in English:	Ossifying Fibroma of the Orbit
   Title in Croatian:	Osificirajući fibrom orbite
   Type of Article:	professional paper
   MeSH:	FIBROMA, OSSIFYING
   Abstract:	Ossifying fibroma of the head and neck is a rare tumour which most frequently involves the upper and lower jaw. It occurs during the third and fourth decade of life. The lesion is usually solitary and well circumscribed. It grows slowly, thinning the surrounding healthy bone tissue. Radiographic appearance depends on the duration of the disease. In the early stage it presents as a sharply circumscribed zone of translucency with single accumulations of calcification. During the further course, with the sharply circumscribed zone of translucency on the periphery, the centrally located accumulations of calcification become denser. The histological appearance is characterised by fibrous tissue, interwoven with bony trabeculae of lamellar bones, which are bordered with osteoblasts and scattered myxomatous stroma. Therapy is surgical and consists of total resection of the tumour, which is the only way to prevent the occurrence of a local recurrence. In this paper we present a rare case of ossifying fibroma of the orbit which involved the zygomatic bone and spread/extended via the large branch of the sphenoid up to the optic canal. The specificity of the therapy in our female patient was that in spite of contact of the tumour with the frontal base of the skull, a neurosurgical approach was not used.

6. Uglešić V, Jokić D, Knežević P, Grgurević J, Milić M. Orthognathic Surgery - Our Concept. Acta Stomatol Croat. 2003;37(3):384.
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   Title in English:	Orthognathic Surgery - Our Concept
   Title in Croatian:	Ortognatska kirurgija - kako mi to radimo
   Type of Article:	congress abstract
   MeSH:	ORTHODONTICS
   Abstract:	Orthognathic surgical treatment is both functional and esthetic. For most of our patients the reason for the first visit is esthetics. The first appointment is made in the combined maxillofacial and orthodontics clinic. During the first appointment we talk to the patient to get a general idea of his/her wishes and medical photographs, jawmodels and X-rays are taken. After collecting all data a general plan for the treatment is made. During the second appointment we discuss our treatment plan together with details of both orthodontic and surgical therapy with the patient. In this discussion we use photographs from our data base and computer simulation.After the final patient’s decision is made, we start with the treatment. Depending on the treatment plan, it starts with either oral surgery or orthodontics. For most of the patients we do not start with treatment before seventeen years of age. After presurgical treatment is finished, we again discuss details of the operation with the patient anda hospital appointment is made. The operation is usually performed on the day of admission, and the hospital stay is 3 to 5 days. We discuss our treatment concept based on patients with the different types of skeletal deformities.

7. Knežević P, Uglešić V, Jokić D, Gašparović S. Ostaoplasty with Autologous Cancellous Hip Bone. Acta Stomatol Croat. 2003;37(3):345.
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   Title in English:	Ostaoplasty with Autologous Cancellous Hip Bone
   Title in Croatian:	Osteoplastika autolognom spongiozom kuka
   Type of Article:	congress abstract
   MeSH:	ALVEOLOPLASTY
   Abstract:	Autologous bone grafts are believed to be the method of choice in the reconstruction of limited mandibular defects and in the reconstruction of the bone defects of the middle and upper part of the face. Autologous bone is an excellent osteoconductive material and is very rarely rejected by the body. The most frequent donor region is crista illiaca. Cortical bone and cancellous bone can be used as a free bone flap.In this study we present the application of autologous cancellous hip bone in the following cases:• Osteoplasty of the alveolar ridge in children withshisis.• Correction of the forehead contour after maxillectomy.• Reconstruction of mandibular defects.The patients were followed during one year after osteoplasty.The success of the implementation of bone grafts was verified with clinical findings, X-rays, in cases of mandibular reconstruction, with pathohistological verification after the removal of the OS material.Apart from a small scar, there was no other damage to the donor region.Osteoplasty with autologous cancellous hip bone graft represents a golden standard in properly chosen indications.

8. Jokić D, Uglešić V, Knežević P, Milić M. Orthodontic treatment of crowding in adult patients (extraction case). Acta Stomatol Croat. 2003;37(3):337-8.
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   Title in English:	Orthodontic treatment of crowding in adult patients (extraction case)
   Title in Croatian:	Ortodontsko liječenje dentofacijalnih deformiteta
   Type of Article:	congress abstract
   MeSH:	CROWDING MALOCCLUSION + therapy ORTHODONTICS, CORRECTIVE
   Abstract:	Disharmony of the jaws presents a great aesthetic and functional problem for patients. The reason for reporting to a clinic is mainly of an aesthetic nature, since most commonly young people are involved, while functional disturbances remain secondary. Such persons have difficulty eating, speaking and breathing. We will present one case of combined dentofacial deformity:PROGNATHISMUS ET LATEROGNATHISMUS MANDIBULARIS.Female patient, 34 years old. From anamnestic data we did not find out whether there were similar problems in the family. The motive for reporting to the clinic was aesthetics, although the patient complained of pain in both temporomandibular joints, difficulty eating and somewhat more difficult pronunciation of certain vocals.A treatment plan was based on:• Analysis of the face, based on profile and en face photographs.• Analysis of occlusion, based on study models.• Roentgen-cephalometry of the profile and AP craniogram, performed on a computer as well as manually, confirmed the above mentioned diagnosis.The treatment was performed exclusively with intraoral and extraoral orthodontic appliances, and we therefore believe that it would be useful to present our experience with such a treatment method.The appearance of the patient after treatment can be seen on the photographs. Repeated cephalometric analyses were performed after completion of the treatment. All parameters were within normal limits, as can be seen from the table presenting pre- and post treatment values. Analysis of the soft tissues also shows significant changes, and relations between the nose, upper lip, lower lip and chin are very good. Today dentofacial deformities are successfully solved. Good study analyses, which serve as the base for planning treatment, guarantee successful treatment. There are very few secrets in ortognatic treatment, but it still requires high professionalism and effectivness.

9. Knežević P, Uglešić V, Jokić D. Quality of Life Assessment for Intraoral Reconstruction. Acta Stomatol Croat. 2002;36(1):39-50.
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   Title in English:	Quality of Life Assessment for Intraoral Reconstruction
   Title in Croatian:	Vrjednovanje kakvoće života nakon intraoralne rekonstrukcije
   Type of Article:	original scientific paper
   MeSH:	SURGICAL FLAPS QUALITY OF LIFE
   Abstract:	The aim of the investigation was to compare the three most commonly used methods of reconstruction of the oral cavity in the University Hospital “Dubrava”, after resection of intraoral carcinoma. In a group of 50 patients, with no statistically significant differences with regard to the stage of disease, local flaps (19 patients), regional pectoralis major flap (11 patients) and free forearm flap (20 patients) were compared. A clinical questionnaire was prepared for evaluation of the success of reconstruction, consisting of two parts. The first part of the questionnaire contained general information on the patient and data on the tumour. The second part of the questionnaire consisted of questions on postoperative functional and aesthetic results. Apart from comparison of the three methods of reconstruction, we also investigated on a sample of 55 patients which parameters were most important for the success of the reconstruction and whether and in what way reconstruction has an effect on postoperative quality of life on a sample of 55 patients. Analysis of the obtained data indicated that none of the three methods of reconstruction were superior in all parameters compared to the other two methods. Free forearm flap did not statistically significantly show the expected theoretic advantage over the regional pectoralis major flap, although it scored higher in almost all parameters. The stage of the disease and extent of resection are the most significant parameters for postoperative result of reconstruction, regardless of the type of flap.

10. Uglešić V, Knežević P, Manojlović S. Planocellular Carcinoma in a Mandibular Cyst. Acta Stomatol Croat. 2001;35(4):501-6.
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    Title in English:	Planocellular Carcinoma in a Mandibular Cyst
    Title in Croatian:	Planocelularni karcinom u cisti donje čeljusti
    Type of Article:	case report
    MeSH:	CARCINOMA, SQUAMOUS CELL ODONTOGENIC CYSTS SURGICAL FLAPS
    Abstract:	An unusual case is presented of a patient with planocellular carcinoma of the mandible which developed through transformation of the epithelium of an odontogenic cyst. The transformation of the epithelium of the cyst into a planocellular carcinoma was histologically verified. Apart from a swelling on the chin there were no other signs of disease in the clinical status. After histological verification of the tumour a wide excision of the skin of the chin and part of the lip was performed, segmental resection of the mandible and selective dissection of both sides of the neck. The skin defect was reconstructed by local rotating flaps and the mandible by a microvascular flap from the fibula.

11. Knežević P, Uglešić V, Jurić M. Indication for the Closure of a Facial Defects by Second Intention Healing. Acta Stomatol Croat. 2001;35(4):491-9.
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    Title in English:	Indication for the Closure of a Facial Defects by Second Intention Healing
    Title in Croatian:	Indikacije za zatvaranje defekata na licu sekundarnim cijeljenjem
    Type of Article:	professional paper
    MeSH:	FACIAL INJURIES
    Abstract:	Closure of a defect in the head and neck area by second intention is an alternative to primary reconstruction. In order to achieve a satisfactory post-operational, aesthetic result it is important to choose the size and localisation of the dermal defect, and to educate the patient on care of the wound for the duration of treatment. As a rule the concave areas of the facial skin are the most suitable for healing by second intention. In cases of well-established indications healing by second intention is a method with excellent esthetical post-operational result. However, if the result is aesthetically unacceptable, the possibility of performing other surgical methods of reconstruction, remains.